Developing a dengue vaccine: progress and future challenges.

“Current Dengue Vaccine Status”

As the impact of dengue expands, a safe and effective vaccine will benefit the world greatly. Recent progress and novel approaches have advanced the field, but many challenges and unanswered questions remain for dengue vaccine developers. The most advanced dengue vaccine candidate, a chimeric yellow fever dengue (CYD) tetravalent vaccine, was the first dengue vaccine tested in a field efficacy ...

Preparing for Dengue Vaccine Introduction: Recommendations from the 1st Dengue v2V International Meeting

Dengue is a major public health concern, resulting in significant morbidity, mortality, and economic and human costs, particularly in developing countries [1–4]. Approximately 40% of the world’s population lives in areas where dengue virus (DENV) transmission occurs, and dengue has recently become a threat in previously unaffected regions [5]. Cases of dengue, and its severe form, dengue haemor...

Prevention and Control Strategies to Counter Dengue Virus Infection

Dengue is currently the highest and rapidly spreading vector-borne viral disease, which can lead to mortality in its severe form. The globally endemic dengue poses as a public health and economic challenge that has been attempted to suppress though application of various prevention and control techniques. Therefore, broad spectrum techniques, that are efficient, cost-effective, and environmenta...

Dengue Vaccine: The Need, the Challenges, and Progress.

Dengue: Challenges for Policy Makers and Vaccine Developers

Because of the increasing incidence, geographic expansion and economic burden of dengue transmission, dengue poses major challenges to policy makers. A vaccine against dengue is urgently needed, but vaccine development has been hampered by the lack of an appropriate animal model, poor understanding of correlates of successful human immunity, the fear of immune enhancement, and viral interferenc...